Engineered photothermal-responsive bacterial platform for in vivo fluorescence imaging-guided photothermal/gene combined breast cancer therapy

   Malignant tumors pose a significant threat to human health, and bacteria-based tumor therapy has made considerable progress in recent years[–6]. Compared with other treatment modalities, this therapeutic approach offers several distinct advantages. Bacteria can be genetically engineered to carry nanomedicines or chemotherapeutic drugs on their surfaces[7], and serve as immune adjuvants to enhance the body's anti-tumor immune response[8,9]. The application of coupling nanophotothermal agents to bacterial surfaces for photothermal therapy has been extensively studied[1–13]. A bio-inorganic system for precise tumor targeting has been developed by covalently linking indocyanine green (ICG)-loaded nanoparticles to the surface of YB1 Salmonella[7]. Reghu and Miyako reported the synthesis of nanoparticle-functionalized bacteria with good biocompatibility and high solubility via a one-step ultrasonication method, which avoids the tedious preparation steps typically required for nanoparticles. The resulting nanoparticles exhibited excellent photothermal conversion capability after incubation with Bifidobacterium[14]. However, the heat generated during high-temperature photothermal therapy may damage surrounding normal tissues and reduce bacterial activity. Therefore, there is an urgent need to develop a safe and effective photothermal approach for tumor therapy.

In biopharmaceuticals, proteomics, and molecular biology research, dialysis is an indispensable and critical step. However, traditional dialysis procedures are cumbersome, time-consuming, and often result in significant sample loss, frequently becoming a bottleneck in experimental efficiency. Now, all that is a thing of the past. The newly launched 60 mL Self-Floating Dialysis Bottle from KEL Biotech, with its innovative design and superior performance, delivers an unprecedented experience of efficiency, convenience, and reliability.

KEL Biotech™ Diphtheria Toxin Variant Protein CRM197

Gey's Balanced Salt Solution (GBSS)
is a phosphate-buffered cell suspension and washing solution, a complete balanced salt solution with a unique combination of salt forms, containing the same five basic ions as EBSS, HBSS, and DPBS.
This solution is sterile-filtered, contains calcium and magnesium, is phenol red-free, and has a pH of 7.4.

KEL Biotech聚顶生物RAN转染试剂产品助力客户发表高水平国际期刊Biomaterials（IF=12.9）

Tired of time-consuming Western Blot transfer procedures, cumbersome operations, and the hazards of methanol? KEL Biotech proudly presents the KELFast™ Rapid Transfer Buffer (10X) — specifically designed for efficient and rapid protein transfer, revolutionizing the traditional blotting experience to make Western Blot faster, safer, and more worry-free!

KLF6 enhances histone H3K23 succinylation by recruiting the p300 complex and synergizes with FOSL2 to upregulate SEMA3C, driving 5-FU resistance in colon cancer cells.